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Abstract

The present invention provides a process for the preparation of a complex of indomethacin and a divalent metal comprising forming a solution by dissolving indomethacin and a salt of said divalent metal in a tertiary amide or cyclic tertiary amide, adding a C.sub.1-4 alkanol or C.sub.3-6 ketone to the solution to precipitate the complex, and separating the precipitated complex from the solution. The present invention also provides a method for the treatment of inflammation or pain in a mammal requiring such treatment, comprising administering to said mammal an anti-inflammatory or analgesically effective amount of a complex of indomethacin and a divalent metal, the complex having the formula [M].sub.2 [indomethacin].sub.4 [S].sub.n, wherein M is the divalent metal, S is a molecule of a tertiary amide or a cyclic tertiary amide, and n is 2 or 3, or of a pharmaceutical composition comprising said complex together with a pharmaceutically acceptable carrier, diluent and/or excipient. The present invention further provides a complex of indomethacin and a divalent metal, the complex having the formula [M].sub.2 [indomethacin].sub.4 [S].sub.n, wherein M, S, and n are defined above, and a pharmaceutical composition comprising this complex together with a pharmaceutically acceptable carrier, diluent and/or excipient.

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First Claim