Inhibition of expression of beta-lactamase using esters of fatty acid alcohols
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United States of America Patent
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Nov 14, 1995
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N/A
app pub date -
May 13, 1993
filing date -
May 13, 1993
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Abstract
A class of chemical compounds comprising fatty acid ester derivatives used to inhibit beta-lactamase production by infectious bacteria. These inhibitors have been found to retard the resistance of certain strains of bacteria to beta-lactam antibiotics, such as penicillin, by interfering with the transcription of the beta-lactamase gene and precluding expression of beta-lactamase. In accordance therewith, these inhibitors permit effective treatment of infections of otherwise resistive bacteria with antibiotics.
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