Eukaryotic transcription protein; host cell factor
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United States of America Patent
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Sep 26, 1995
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app pub date -
Apr 12, 1993
filing date -
Dec 4, 1992
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Abstract
Host Cell Factor (HCF), a eukaryotic cellular protein involved in transcription, nucleic acids encoding HCF, and methods of using HCF and HCF-encoding nucleic acids are provided. HCF activity is disclosed to comprise a collection of polypeptides encoded by a structural gene encoding a parent protein of 2039 amino acids. HCF-specific binding compounds are disclose including antibodies to HCF epitopes. Because HCF is required for the transcription of a number of vital genes such as the immediate early genes of Herpes Simplex Virus, the invention provides HCF-based methods for screening chemical libraries for regulators of viral transcription. Such regulators are used in the treatment of viral infections by modulating the transcription of certain viral genes.
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