Quinolone carboxylic acid derivatives

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United States of America Patent

PATENT NO 5447926
SERIAL NO

08305977

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Abstract

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A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in living bodies, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatments and prevention of various infectious diseases in clinics.

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Patent Owner(s)

Patent OwnerAddress
BAUSCH & LOMB INCORPORATEDONE BAUSCH & LOMB PLACE ROCHESTER NY 14604

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Asaoka, Takemitsu Narita, JP 28 111
Kawahara, Ryuichi Ichikawa, JP 6 31
Konno, Fujiko Tomisato, JP 7 46
Kuraishi, Tasdayuki Chiba, JP 1 7
Matsuda, Hideaki Abiko, JP 116 1160
Shibata, Akihiro Yachiyo, JP 73 666
Taido, Naokata Funabashi, JP 10 103
Takeda, Sunao Ichihara, JP 47 1002

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