Process for the preparation of microspheres made of a biodegradable polymeric material
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United States of America Patent
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Aug 29, 1995
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N/A
app pub date -
Jul 16, 1992
filing date -
Jul 22, 1991
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Abstract
The process is aimed at providing a composition designed for the sustained and controlled release of medicamentous peptide substances, obtained in the form of microspheres of a biodegradable polymeric material incorporating said medicamentous substance. It consists in converting first a water-soluble peptide or peptide salt into a water-insoluble peptide, respectively peptide salt. The following steps include preparing an organic-aqueous emulsion and then extracting the organic solvent in an excess of aqueous medium.
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