Method of producing .alpha.-hydroxyisobutyramide from acetone cyanohydrin by nitril hydratase
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United States of America Patent
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Aug 22, 1995
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N/A
app pub date -
Aug 19, 1992
filing date -
Aug 16, 1991
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Abstract
A culture liquid of microorganisms having an ability of producing .alpha.-hydroxyisobutylamide from acetone cyanhydrin or the cultivated cells of the microorganisms or the processed cells of them is/are reacted to acetone cyanhydrin in an aqueous medium to produce .alpha.-hydroxyisobutylamide. The amide is reacted with water and/or an aliphatic alcohol in the presence of a solid acid catalyst at a temperature of 150.degree. C. or higher in a gaseous phase or a gaseous-liquid mixed phase to produce an .alpha.,.beta.-unsaturated carboxylate or an aliphatic alcohol or an .alpha.,.beta.-unsaturated carboxylic acid.
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