Antibodies catalyzing deamidation of proteins

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United States of America Patent

PATENT NO 5439812
SERIAL NO

07865216

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Abstract

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A hapten is described which may be used to elicit antibodies that catalyze the deamidation of asparginyl-glycyl dipeptides to form two products, the isoaspartyl-glycyl dipeptide and the aspartyl-glycyl dipeptide. A general synthetic scheme is also presented which shows how to modify the hapten to provide specificity for a particular protein in the antibodies that are elicited by the (modified) hapten. Antibodies which catalyze the the deamidation reaction are also described.

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Patent Owner(s)

Patent OwnerAddress
PENNSYLVANIA RESEARCH CORPORATION THE114 KERN GRADUATE BUILDING UNIVERSITY PARK PA 16802

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benkovic, Stephen J State College, PA 63 1134
Gibbs, Richard A State College, PA 12 559
Taylor, Scott D State College, PA 36 300

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