Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency
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United States of America Patent
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Aug 1, 1995
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app pub date -
Oct 14, 1992
filing date -
May 1, 1989
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Abstract
Improved methods for the GC/MS analysis of sulfhydryl amino acids and methylmalonic acids in samples of body fluids are provided. Additionally a method for combined assay of sulfhydryl amino acids particularly total homocysteine and combined creatine/creatinine levels in samples of body fluids provided. The information provided by the methods described is useful in the detection of the presence of cobalamin or folate deficiencies in individuals and in distinguishing between the two deficiencies.
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