Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
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United States of America Patent
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Aug 1, 1995
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app pub date -
Dec 14, 1993
filing date -
Nov 24, 1992
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Abstract
The resultant compounds of the formula (I) have an excellent antitumor activity. A process for preparation of a compound represented by the formula ##STR1## wherein X.sup.1 and X.sup.2 each independently represent hydrogen atom, halogen atom, amino group, mono- or di-lower alkylamino group, hydroxyl group, lower alkoxy group, aralkoxy group, carboxyl group, lower alkoxycarbonyl group, lower alkanoyloxy group or lower alkyl group, and R is hydrogen atom, amino group, formylamino group, lower alkanoylamino group, mono- or di-lower alkylamino group, hydroxyl group, lower alkoxy group, aralkoxy group, aralkyl group or lower alkyl group, which comprises cultivating a microorganism having an ability to glycosylate a compound represented by the formula ##STR2## wherein X.sup.1, X.sup.2 and R have the same meanings as defined above, in a nutrient medium containing the compound of the above formula (II), and recovering the formed compound of the formula (I) from the culture medium.
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