Isolation and structure of spongistatin 1
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United States of America Patent
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Jul 25, 1995
Grant Date -
N/A
app pub date -
Jan 19, 1993
filing date -
Jan 19, 1993
priority date (Note) -
Expired
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Abstract
An Eastern Indian Ocean marine sponge in the genus Spongia was located in the Republic of the Maldives and found to contain a structurally unprecedented macrocyclic lactone named spongistatin 1. The new perhydropyran-containing structure, as shown below, was found to be remarkably potent and specific, log molar TCI.sub.50 to <-10, against twenty human cancer cell lines in the U.S. National Cancer Institute's panel of sixty.
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