Phenylalanine analogs of bombesin
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United States of America Patent
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Jun 27, 1995
Issued Date -
N/A
app pub date -
Jun 22, 1994
filing date -
Feb 7, 1992
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Expired
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Abstract
Disclosed are Agonists and Antagonists of bombesin which are derivatives of naturally occurring bombesin possessing modified derivatives of phenylalanine. Agonist and antagonist activities are confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions. Use of these peptides may be useful for stimulating or antagonising growth of tissues, especially lung, and of digestion. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin analog.
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