HIV protease inhibitors useful for the treatment of AIDS

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United States of America Patent

PATENT NO 5413999
SERIAL NO

08059038

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, or R.sup.1 and R.sup.2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of treating infection by HIV are also described.

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Patent Owner(s)

  • MERCK SHARP & DOHME CORP.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dorsey, Bruce D Harleysville, PA 67 649
Guare, James P Quakertown, PA 8 182
Holloway, M Katharine Lansdale, PA 21 356
Hungate, Randall W Lansdale, PA 48 1311
Levin, Rhonda B Lafayette Hill, PA 4 134
Vacca, Joseph P Telford, PA 111 1099

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