Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith

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United States of America Patent

PATENT NO 5409949
SERIAL NO

07987280

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Abstract

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The invention provides new methylen-indole derivatives of formula (I) ##STR1## wherein R is a group ##STR2## in which R.sub.4 is hydrogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyloxy, carboxy, nitro or NHR.sub.7, wherein R.sub.7 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl or halogen; and R.sub.6 is hydrogen or C.sub.1 -C.sub.6 alkyl; n is zero, 1 or 2; R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, cyano, carboxyl, nitro or --NHR.sub.7 in which R.sub.7 is as defined above; R.sub.3 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof; and wherein, when, at the same time, R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or cyano and R.sub.3 is hydrogen, R.sub.1 and n being as defined above, then at least one of R.sub.4, R.sub.5 and R.sub.6 is other than hydrogen, which are useful as tyrosine kinase inhibitors.

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Patent Owner(s)

Patent OwnerAddress
FARMITALLIA CARLO ERBA S R LVIA CARLO IMBONATI 24 20159 MILAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buzzetti, Franco Monza, IT 31 565
Colombo, Maristella Cesano Boscone, IT 7 168
Longo, Antonio Milan, IT 69 11279

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