DNA's encoding signal peptides
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United States of America Patent
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Apr 25, 1995
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N/A
app pub date -
Feb 16, 1989
filing date -
Feb 16, 1988
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Expired
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Abstract
Novel signal peptides capable of functioning in yeasts have the amino acid sequence: Met-A.sub.1 -A.sub.2 -X-B-C-D-E-F wherein A.sub.1 is a peptide chain composed of 1-3 amino acids each selected from the group consisting of Arg, Ser, Lys and His, A.sub.2 is a peptide chain composed of 1-3 amino acids, X is a peptide chain composed of 8-10 hydrophobic amino acids, B is Pro or Ser, C is Gly or Pro, D Cys, Ala, Leu, Ser, Thr and Val, E is Trp or Gln and F is Ala or Gly. DNA sequences coding for these signal peptides can be used for the secretory expression of heterologous proteins in yeasts.
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