MEKK protein, capable of phosphorylating MEK

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United States of America Patent

PATENT NO 5405941
SERIAL NO

08049254

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Abstract

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The isolated nucleic acid sequence for MEKK, the MEKK amino acid sequence and protein, antibodies to MEKK, and methods for using such sequences, proteins and antibodies are described. The amino acid sequence of MEKK (MEK kinase), was elucidated from a cDNA sequence encoding a protein of 672 amino acid residues (73 kilodaltons). When MEKK is expressed, it phosphorylates and activates MEK. Phosphorylation and activation of MEK by MEKK is independent of Raf, a growth factor regulated protein kinase that also phosphorylates MEK. Thus, MEKK and Raf converge at MEK in the protein kinase network mediating the activation of MAPKs by hormones, growth factors, and neurotransmitters.

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Patent OwnerAddress
NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE1400 JACKSON STREET DENVER CO 80206

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Johnson, Gary L Boulder, CO 51 657

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