Biocompatible, low protein adsorption affinity matrix
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United States of America Patent
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Apr 4, 1995
Issued Date -
N/A
app pub date -
Apr 8, 1991
filing date -
Mar 6, 1991
priority date (Note) -
Expired
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Abstract
Affinity matrices useful for the chromatography and immobilization of biological materials and the method of preparing and using the same are disclosed. The affinity supports are based on hydrated polyurethane polymers which have been activated to provide a means for covalently attaching a variety of bioaffinity agents. The hydrated polymer matrices are characterized by their biocompatibility and resistance to nonspecific protein adsorption. Preferably, the prepolymers used to prepare the hydrated polymers are isocyanate-capped oxyethylene-based diols or polyols, at least 75% of said diols and polyols having a molecular weight of 7000 to about 30,000.
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