Water soluble bis-dioxopiperazine derivatives
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United States of America Patent
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Feb 28, 1995
Grant Date -
N/A
app pub date -
Mar 2, 1992
filing date -
Jul 4, 1990
priority date (Note) -
Expired
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Abstract
A pharmaceutically-acceptable acid addition salt of a bis-dioxopiperazine derivative of the formula (I): ##STR1## which derivative exhibits anti-tumor potency and is water-soluble, wherein R.sup.1 is a C.sub.1-6 alkyl group, R.sup.2 represents a hydrogen atom or: ##STR2## R.sup.3 represents a hydrogen atom, a C.sub.1-6 alkyl group or (CH.sub.2).sub.n A, wherein A respresents carboxyl, benzyloxycarbonyl, mercapto, amino, benzyloxycarbonylamino or: ##STR3## and n is an integer of 1, 2, 3 or 4, and R.sup.4 represents a hydrogen atom or is coupled with R.sup.3 into a 5-membered ring, which may contain one sulfur atom as an additional ring heteroatom.
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