Compositions and methods for protein structural determinations
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United States of America Patent
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Feb 28, 1995
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N/A
app pub date -
Feb 5, 1993
filing date -
Feb 5, 1993
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Expired
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Abstract
A method for determining three-dimensional structural information of a protein involves producing the protein in a form substantially labeled with .sup.13 C or .sup.15 N or both and subjecting the protein to nuclear magnetic resonance spectroscopic analysis. The isotopically labeled protein is produced by a method which involves producing a substantially labeled microbial protein hydrolysate, subjecting the protein hydrolyzate to cation exchange chromatography to produce a partially purified labeled amino acid mixture, subjecting the partially purified labeled amino acid mixture to anion exchange chromatography to produce a purified labeled amino acid mixture and supplementing the purified labeled amino acid mixture with isotopically labeled cysteine.
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