Transdermal therapeutical system with physostigmine as active component and process for the production thereof
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United States of America Patent
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Feb 21, 1995
Issued Date -
N/A
app pub date -
Apr 26, 1993
filing date -
Dec 22, 1988
priority date (Note) -
Expired
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Abstract
The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active substances, an active substance deposit comprising at least one auxiliary agent with supporting and distributing function in the form of a textile fabric material, a matrix surrounding said deposit from all sides, and optionally a removable protective layer, the matrix of which comprises 10-90%-wt polymeric material selected from the group consisting of polymers on the basis of acrylate and/or methacrylate and esters of hydrogenated colophonium, 0-30%-wt softener on the basis of hydrocarbons and/or esters, and that the active substance deposit immediately after its production comprises 15-85%-wt of a 0.1-70%-wt physostigmine solution.
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