Stability-enhanced variants of parathyroid hormone
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United States of America Patent
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Jan 17, 1995
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app pub date -
Apr 3, 1992
filing date -
Apr 3, 1992
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Abstract
Herein described are variants of parathyroid hormone that retain significant PTH activity and are substantially resistant to trypsin and trypsin-like enzymes. The variants are useful pharmaceutically, to treat bone disorders such as osteoporosis and in other therapeutic applications. Specific embodiments of the invention include [His.sup.25 ]PTH and [His.sup.25 His.sup.26 Leu.sup.27 ]PTH.
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