Peg-interferon conjugates
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United States of America Patent
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Jan 17, 1995
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N/A
app pub date -
Aug 26, 1992
filing date -
Aug 26, 1992
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Abstract
Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in vivo hydrolytic cleavage, have enhanced in vivo half life, and reduce the immunogenicity of the interferon while maintaining biological activity.
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