Process for preparing optically active 2-aryl-alkanoic acids, in particular 2-aryl-propionic acids
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United States of America Patent
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Jan 10, 1995
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app pub date -
May 16, 1990
filing date -
May 16, 1989
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Abstract
A chemical process is disclosed for the preparation of a pharmaceutically active compound in stereospecific form selected from the group of compounds having the formula: ##STR1## and their physiologically compatible salts and esters, wherein R is a lower alkyl and Ar a monocyclic, polycyclic or orthocondensed polycyclic aromatic group having up to 12 carbon atoms in the aromatic ring, and which may be substituted or unsubstituted in the aromatic ring, comprising the steps: a) reacting a carbonyl substrate of the formula: ##STR2## where R and Ar have the meanings given above, with a stereospecific reagent in the presence of a reducing agent and an organic solvent to form the enatiomeric carbinol and b) reacting the enantiomeric carbinol obtained to form the end product.
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