Importance

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Abstract

A medical device has one or more polymeric substrates each treated with a chemically binding coating to make each polymeric substrate compatible for contact with blood. A modified natural and substantially hydrophilic blood protein bonds permanently to each substrate. The protein is functionalized with bonding sites so after application thereof to each substrate and if subject to sufficient radiation, free radicals created on each substrate and the functionalized protein chemically bind. A modifier added to the protein creates sites by functionalizing it before application to each substrate. The functionalized combination is applied to each substrate. The protein is human or animal albumin as bovine. The modifier are molecules having an epoxy function for attachment to the human or animal albumin. An unsaturated double bond forms or accepts free radicals at bonding sites. The modifier added to the protein is glycidyl acrylate. The bonding sites and the unsaturated double bond for attachment to free radicals are each a single carbon atom of a carbon-carbon bond which together form a covalent bond. The radiation is gamma or electron beam. The polymeric substrates in the extracorporeal circuit permit penetration of gamma rays. A method has the steps of selecting the protein; adding the modifier for creating bonding sites to functionalize the protein before application to each polymeric substrate; applying the combination to each substrate, and creating free radicals on each substrate and the combination. The method includes irradiating the combination sufficiently to create free radicals on each coated substrate as the bonding sites for chemically binding.

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First Claim