Vitamin D analogues
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United States of America Patent
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Dec 20, 1994
Grant Date -
N/A
app pub date -
Jul 23, 1992
filing date -
Mar 30, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to compounds of formula I ##STR1## in which formula X is hydrogen or hydroxy; Y is oxygen, sulphur, or oxidized sulfur (S(O) or S(O.sub.2)); R.sup.1 and R.sup.2, which may be the same or different, stand for hydrogen or C.sub.1 -C.sub.6 hydrocarbyl, or R.sup.1 and R.sup.2, taken together with the carbon atom (starred in formula I) bearing the group X, form a C.sub.3 -C.sub.8 carbocyclic ring; Q is a C.sub.1 -C.sub.8 hydrocarbylene diradical. R.sup.3 is hydrogen or C.sub.1 -C.sub.6 hydrocarbyl. R.sup.1, R.sup.2 and/or Q, may be optionally substituted with one or more deuterium or fluorine atoms; n is 0 or 1. The present compounds show antiinflammatory and immunomodulating effects as well as a strong activity in inducing cell differentiation and inhibiting undesirable proliferation of certain cancer and skin cells.
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