Modulator agent and use thereof
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United States of America Patent
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Nov 29, 1994
Issued Date -
N/A
app pub date -
Jun 19, 1992
filing date -
Apr 10, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Sensitizing tumoral cells to anticancerous drugs and/or inhibiting the tumoral cells resistance to antitumoral drugs employing as a modulator agent a vinca alkaloid dimer, analog to vinblastine or vincristine, with a low cytotoxicity or devoid of cytotoxicity, comprising at least one stereoisomerism different from that of vinblastine or vincristine in the C-14', C-16' or C-20' position. Notably, the modulator agent may have the R absolute configuration in the C-16' position.
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