Convenient process for the preparation of chiral or racemic phenylalaninols and their N-blocked derivatives
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United States of America Patent
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Nov 22, 1994
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N/A
app pub date -
Jun 4, 1993
filing date -
Jun 4, 1993
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Expired
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Abstract
This invention pertains to an improved process for preparing chiral or racemic phenylalaninol (PAO) by hydrogenation of L(+)- or racemic 2-amino-1-phenyl-1,3-propanediol (APPD) in the presence of a strong volatile acid. Furthermore, a more valuable form of PAO such like N-blocked PAO was found to be directly produceable from the hydrogenation mixture without isolation of PAO, when a volatile acid was used as the medium of the hydrogenation reaction.
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