Method of preparing human conjunctival mast cells for mast cell stabilization assays
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
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Nov 1, 1994
Grant Date -
N/A
app pub date -
Oct 8, 1993
filing date -
Oct 8, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
By allowing the mast cell enriched population of human conjunctival tissue cells to incubate for a minimum of about forty (40) hours post enzymatic digestion, the treatment window between spontaneous histamine release and anti-human IgE stimulated histamine release is increased. Culturing the human conjunctival tissue mast cells decreases the spontaneous release of histamine and increases the anti-IgE stimulated histamine release, greater than ten fold over spontaneous, at time points over forty (40) hours. This treatment window is sufficient to detect a compound's stabilizing or anti-allergic activity.
First Claim
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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ALCON LABORATORIES INC | 6201 SOUTH FREEWAY FORT WORTH TEXAS 76134 UNITED STATES OF AMERICA |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Miller, Steven T | Arlington, TX | 42 | 335 |
# of filed Patents : 42 Total Citations : 335 | |||
Yanni, John M | Burleson, TX | 98 | 1348 |
# of filed Patents : 98 Total Citations : 1348 |
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Patent Citation Ranking
- 5 Citation Count
- C12Q Class
- 2.68 % this patent is cited more than
- 31 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
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Jan 26, 2018 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Nov 01, 1998 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Nov 01, 1998 |
Nov 01, 1998 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | |
Aug 12, 1998 | REMI | MAINTENANCE FEE REMINDER MAILED | |
Nov 01, 1994 | I | Issuance | |
Oct 08, 1993 | F | Filing | |
Oct 08, 1993 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MILLER, STEVEN T.;YANNI, JOHN M.;REEL/FRAME:006738/0051 Owner name: ALCON LABORATORIES, INC., TEXAS Effective Date: Oct 08, 1993 |

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