Cyclobutyl oligonucleotide surrogates
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United States of America Patent
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Oct 25, 1994
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N/A
app pub date -
Dec 13, 1991
filing date -
Dec 13, 1991
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Abstract
Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.
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