Cytotoxic agents
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United States of America Patent
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Oct 18, 1994
Issued Date -
N/A
app pub date -
Sep 17, 1993
filing date -
Nov 6, 1992
priority date (Note) -
Expired
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Abstract
The invention relates to pharmaceutical compositions comprising an effective cytotoxic amount of: ##STR1## Wherein R represents Ac or H; R' represents: ##STR2## OH; and R' represents: ##STR3## these new compounds demonstrate surprising tubulin binding activity and cytotoxicity.
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