Imidazol-2-yl derivatives of substituted bicyclic compounds

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United States of America Patent

PATENT NO 5356920
SERIAL NO

07915835

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Abstract

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Compounds having formula (I) ##STR1## wherein Z is --O-- or --CH.sub.2 --; n is 1-6; R is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl or optionally substituted phenyl-C.sub.1 -C.sub.3 alkyl; R.sub.2 is C.sub.1 -C.sub.8 -alkyl, aryl-C.sub.1 -C.sub.3 alkyl, C.sub.5 -C.sub.8 cycloalkyl or C.sub.5 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.3 alkyl; each of R.sub.3 and R.sub.4 independently is hydrogen or C.sub.1 -C.sub.4 alkyl, or taken together with the carbon atom to which they are linked form a C.sub.3 -C.sub.6 cycloalkyl ring; Q is --OR' or --NR'R' in which R' and R' are as herein defined, or Q is C.sub.1 -C.sub.8 alkyl, phenyl, phenyl-C.sub.1 -C.sub.3 -alkyl, C.sub.5 -C.sub.8 cycloalkyl or C.sub.5 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.3 alkyl, in which both the phenyl and cycloalkyl rings or moieties are optionally substituted as herein defined; and the pharmaceutically acceptable salts thereof; are useful in particular as antidislipidaemic and antiatherosclerotic agents.

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Patent Owner(s)

Patent OwnerAddress
FARMITALIA CARLO ERBA SRL ITALIAN BODY CORPORATEVIA CARLO IMBONATI 24 20159 MILAN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chiari, Augusto Florence, IT 3 5
Cozzi, Paolo Milan, IT 41 137
Fancelli, Daniele Milan, IT 43 288
Ghiselli, Giancarlo Busto Arsizio, IT 2 1
Severino, Dino Milan, IT 5 33

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