Avermectin difluoro derivatives
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United States of America Patent
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Sep 27, 1994
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N/A
app pub date -
Jun 10, 1993
filing date -
Apr 29, 1992
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Expired
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Abstract
Avermectin derivatives are disclosed which incorporate two fluorine atoms at the 4' monosaccharide position, the 4' disaccharide position or the 23 position. Avermectin aglycone derivatives are also disclosed which incorporate two fluorine atoms at position 13 or 23. These difluoro avermectin analogs are derived from corresponding ketones and enones which in turn are prepared by chemical modification of naturally occurring avermectins. These compounds are used as antiparisitic, insecticidal and antihelmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.
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