Immobilization of an anti-thrombogenic substance with a photo-reactive azide and a photo-crosslinking material
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United States of America Patent
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Sep 20, 1994
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N/A
app pub date -
Oct 19, 1992
filing date -
Nov 1, 1991
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Abstract
An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive azide derivative macromolecular material to a base to form a bonding layer, coating the bonding layer with a macromolecular layer composed of a water-soluble photo-crosslinking macromolecular material containing the anti-thrombogenic substance, and irradiating the base with ultraviolet light with the bonding layer and the macromolecular layer formed thereon to develop inter-molecular covalent bonding in the bonding layer. The macromolecular layer containing the anti-thrombogenic substance is thus fixed onto the base. Concurrently, the anti-thrombogenic substance is immobilized in the macromolecular layer which is crosslinked. The azide derivative can be poly-m-azidostyrene, copolymers, of poly-m-aziodstyrene with styrene and copolymers of poly-m-azidostyrene with methyl methacrylate. The water-soluble photo-crosslinking macromolecular material can be a copolymer of a photo-dimeric monomer with a water-soluble monomer or a copolymer of a photo-reactive azide with a water-soluble monomer.
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