Process for biological production of amides with R. rhodochrous J-1
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United States of America Patent
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Aug 2, 1994
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Oct 15, 1991
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Sep 18, 1987
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Abstract
In a process for biological production of an amide wherein a nitrile is hydrated into a corresponding amide by the action of a nitrile hydratase originated in a microorganism, the improvement which comprises the use of nitrile hydratase which is obtained by culturing a microorganism of the species Rhodococcus rhodochrous in the presence of a cobalt ion. Aromatic nitriles such as a cyanopyridine as well as aliphatic nitrile such as acrylonitrile are hydrated into the corresponding amides.
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