Di-N-acetyl lysoganglioside compositions
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United States of America Patent
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Jul 19, 1994
Issued Date -
N/A
app pub date -
Jul 27, 1992
filing date -
Dec 28, 1989
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Expired
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Abstract
The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ; n is 12 or 14; R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.
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