Di-N-acetyl lysoganglioside compositions

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United States of America Patent

PATENT NO 5330977
SERIAL NO

07918611

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Abstract

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The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ; n is 12 or 14; R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.

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Patent Owner(s)

Patent OwnerAddress
THE WELLCOME FOUNDATION LIMITEDGREENFORD MIDDLESEX UB6 0NN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cavallo, Giovanni Rome, IT 22 221
Tubaro, Ezio Rome, IT 4 32

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