Cyclic antitumor compounds
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United States of America Patent
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Jun 7, 1994
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N/A
app pub date -
Aug 18, 1992
filing date -
Jun 4, 1991
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Expired
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Abstract
The present invention relates to certain substituted tetracyclic fused quinoline derivatives of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo, methoxy or amino; R.sup.2 is hydrogen, hydroxy, methoxy or amino; R.sup.3 is hydrogen, hydroxy, methoxy, methoxymethoxy, amino, --OCONH.sub.2, [2(5H)-3,4-dihydro-3-oxyfuranone], 2-hydroxyethoxy, 2-aminoethoxy, 3-hydroxypropoxy or 3-aminopropoxy; or taken together with R.sup.2 or R.sup.4, methylenedioxy or ethylenedioxy; R.sup.4 is hydrogen, hydroxy or amino; Z is --CH.sub.2 --, --O-- or --NH--; and a) X.sup.1 is hydrogen; X.sup.2 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo or methoxy; and X.sup.3 is hydrogen or hydroxy; or b) X.sup.2 taken together with X.sup.3 is methylenedioxy or ethylenedioxy, and X.sup.1 is hydrogen or a pharmaceutically acceptable salt thereof provided that: i) at least one of R.sup.1 through R.sup.4 is other than hydrogen.
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