Substituted amidines having high binding to the sigma receptor and the use thereof
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United States of America Patent
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May 3, 1994
Issued Date -
N/A
app pub date -
Mar 30, 1992
filing date -
Aug 30, 1990
priority date (Note) -
Expired
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Abstract
N,N'-disubstituted-amidines, e.g., of the formula ##STR1## wherein R, R' and R' are substituted or unsubstituted hydrocarbon and/or heterocyclic groups. Methods are provided for the treatment or prophylaxis of anxiety in an animal, for treating psychosis, and for treating hypertension by administering an effective amount of an N,N'-disubstituted amidine which, preferably, has a high affinity for the sigma receptor.
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