Polynucleotide constructs for secreted glycosylated plasminogen activator inhibitor-2 (PAI-2)
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United States of America Patent
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Mar 29, 1994
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May 6, 1991
filing date -
Sep 5, 1989
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Abstract
This invention relates to PAI-2 and its expression as a recombinant molecule in eukaryotic cell lines as a glycosylated secreted molecule, to the constructs expressing it, to host cells expressing it, to compositions comprising it, to methods of treatment, prophylaxis and diagnosis using it and to antibodies raised against it. The invention also provides a 414 amino acid form of PAI-2 wherein the N-terminal methionine residue is deleted, a 60 kD glycosylated secreted recombinant form of PAI-2 and compositions and methods using these molecules. The invention further relates to a novel synthetic signal peptide.
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