Immunosuppressive macrocyclic compounds
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United States of America Patent
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Mar 22, 1994
Grant Date -
N/A
app pub date -
Sep 11, 1992
filing date -
Mar 13, 1990
priority date (Note) -
Expired
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Abstract
There are provided compounds of formula (I), wherein R.sup.1 represents H, OH or alkoxy; R.sup.2 represents H; in addition R.sup.1 and R.sup.2 may together represent a second bond between the carbon atoms to which they are attached; R.sup.3 represents methyl, ethyl, propyl or allyl; R.sup.4 represents H, OH, alkyl, alkoxy, halogen, amino, S-alkyl, NHCHO or NHCO-alkyl; n represents 1 or 2; X represents O, (H, OH), (H, H) or .dbd.NH; and Y represents an optionally substituted cyclohexyl or substituted cyclopentyl group; with various provisos. The compounds are useful, inter alia, as immunosuppressive agents.
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