Process for preparing a single enantiomer of a lactam using lactamase
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United States of America Patent
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Feb 8, 1994
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May 20, 1993
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Oct 16, 1989
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Abstract
Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides.
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