Preparation of purified optical isomers of desflurane
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United States of America Patent
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Feb 1, 1994
Issued Date -
N/A
app pub date -
Apr 15, 1993
filing date -
Dec 4, 1991
priority date (Note) -
Expired
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Abstract
A process for the preparation of highly purified optical isomers of desflurane, i.e. 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, is described wherein the highly purified opposite optical isomer of iso-flurane is reacted with bromine trifluoride in the cold, preferably in the presence of a solvent. A preferred solvent is bromine. The highly purified positive isomer of desflurane is advantageous over the negative isomer or the racemate.
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