Di-N-deacetyl-lysogangliosides

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United States of America Patent

PATENT NO 5281702
SERIAL NO

07689901

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Abstract

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The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ; n is 12 or 14; R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.

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Patent Owner(s)

Patent OwnerAddress
WELLCOME FOUNDATION LIMITED THE A CORPORATION OF THE UNITED KINGDOMUNICORN HOUSE 160 EUSTON ROAD LONDON NW1 2BP UNITED KINGDOM

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cavallo, Giovanni Rome, IT 22 221
Tubaro, Ezio Rome, IT 4 32

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