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Abstract

The subject of the present invention is compounds which correspond to the following general formula: ##STR1## in which R.sub.1 and R.sub.3 independently of one another represent H, an alkyl, alkenyl, cycloalkyl, aryl, arylalkyl or an alkylaryl group, a heterocycle, or groups which are unsubstituted or substituted, in particular by one or more hydroxyl or alkoxy groups or halogen; n represents an integer from 1 to 5; i in each case takes values from 1 to n for the n successive ##STR2## links; R.sub.2, R.sub.4.sup.i and R.sub.5.sup.i independently of one another represent H, an alkyl, alkenyl, aryl, alkoxy, hydroxyalkyl, alkoxyalkyl, amido, acyl or carboxyalkyl group, or a salt, or an alkyl ester of the latter; or R.sub.4.sup.i and R.sub.5.sup.i together form an oxo group ##STR3## R.sub.6 and R.sub.7 represent H, or R.sub.6 and R.sub.7 together form an oxo group ##STR4## x represents a 5- or 6-membered heterocycle which contains at least one nitrogen atom, or, in the event that ##STR5## where R.sub.8 and R.sub.9 independently represent H, alkyl, aryl or arylalkyl, and R.sub.10 represents H, alkyl, aryl or arylalkyl. The present invention likewise relates to coordination complexes between these ligands and a metal as well as to kits containing these ligands and to reagents which permit the formation of a coordination complex between the ligand and the metals. More particularly, the present invention relates to complexes between these ligands and technetium .sup.99m Tc, which complexes can be used as diagnostic agents for brain imaging, heart imaging and blood imaging.

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First Claim