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Abstract

Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C.sub.1 -C.sub.6 alkyl; each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is independently: a) hydrogen, halogen, hydroxy, cyano or nitro; b) C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by halogen, c) C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkylthio; d) C.sub.1 -C.sub.6 alkyl-sulfonyl; e) a substituted amine group --NR.sub.7 R.sub.8 ; f) a --COR.sub.12 group; or g) two adjacent groups of R.sub.3, R.sub.4, R.sub.5 and R.sub.6, taken together, form a C.sub.1 -C.sub.4 alkylenedioxy group; each of R.sub.1 and R.sub.2 independently is hydrogen, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 alkenyl or C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl; or R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous nervous system, in particular as antidepressant, antiobesity antismoking and anti-alcoholabuse agents.

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