Glucose isomerases with improved affinity for D-glucose
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United States of America Patent
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Nov 30, 1993
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N/A
app pub date -
Sep 19, 1991
filing date -
Sep 19, 1991
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Expired
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Abstract
A genetically engineered glucose isomerase with improved affinity for D-glucose and the method of preparation of such a glucose isomerase are disclosed. The glucose isomerase is obtained by mutagenizing the gene of a naturally occurring glucose isomerase such that a smaller amino acid replaces a larger amino acid in the catalytic site. In an especially advantageous embodiment of the present invention, the Clostridium glucose isomerase sequence is mutated and the residue replaced with a smaller amino acid is either Trp.sub.139 or Val.sub.186.
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