Method of forming uniform polymer spheres, composite particles and polymer encapsulated particles
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United States of America Patent
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Nov 23, 1993
Issued Date -
N/A
app pub date -
Jan 17, 1992
filing date -
Jan 24, 1991
priority date (Note) -
Expired
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Abstract
A method for forming fine polymer particles, including core/shell polymer composite particles and polymer-encapsulated liposome particles. A polymer solution is formed using a selective solvent which enables the polymer to be precipitated from the solution upon a change in condition thereof. The change in condition may be effected by lowering of the temperature of the solution and/or introducing a non-solvent to the solution. With respect to the formation of the polymer-encapsulated liposome particles, the liposome particles are included when the polymer solution is formed. One embodiment of the method for forming the core/shell particles includes the selective solvent being immiscible with water to form the polymer solution (oil phase), the addition of deionized water containing an emulsifier to the solution, forming the emulsion, cooling the resulting emulsion to precipitate a one polymer from the emulsion as oil drops leaving the other polymer in solution therein, evaporating the selective solvent solidifying the other polymer thereby encapsulating the one polymer forming the core/shell particles.
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