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Abstract

The invention concerns substituted pyrrole compounds and their pharmaceutical applications. The compounds of the invention are potent inhibitors of lipoxygenase and cyclo-oxygenase and therefore are suitable to treat the set of rheumatic illnesses and to prevent allergically induced ailments. The compounds have the general formula: ##STR1## where R.sup.1 denotes a C.sub.1 -C.sub.12 alkyl group, R.sup.2 denotes a hydrogen atom or a C.sub.1 -C.sub.12 alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom and the nitrogen atom to which they are bound form a ring of 5 to 8 links which may contain a sulfur heteroatom or a carbonyl group and may be substituted with one or two C.sub.1 -C.sub.4 alkyl groups, each time two of the residues R.sup.3, R.sup.4 and R.sup.5 independently from one another represent a hydrogen atom, a C.sub.5 -C.sub.8 cycloalkyl group, a C.sub.1 -C.sub.12 alkyl group or an aryl group which may be substituted by one or two residues selected from a halogen atom, a nitro-, a C.sub.1 -C.sub.4 alkoxy-, a hydroxy-, a C.sub.1 -C.sub.4 alkyl- or phenoxy-group, and where the third of the residues R.sup.3, R.sup.4 and R.sup.5 denotes --CHO, --CO.sub.2 H, --COSC.sub.1 -C.sub.4 -alkyl or A--X, with A being a straight-chain or a branched C.sub.1 -C.sub.8 alkylene group which may be interrupted by an oxygen heteroatom or a carbonyl group or being a C.sub.2 -C.sub.8 alkenylene group, X being CO.sub.2 H, SO.sub.3 H, CHO, OH or SH, as well as their pharmaceutically compatible salts and esters, for pharmaceutical applications.

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