Antigenic epitopes present on membrane-bound but not secreted IgE
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United States of America Patent
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Nov 9, 1993
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N/A
app pub date -
Jan 23, 1990
filing date -
Dec 31, 1987
priority date (Note) -
Expired
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Abstract
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. The epitope can be exploited for therapy and diagnosis. For example, antibodies or immunotoxins specific for the epitopes associated with the anchor domain of IgE can be used to selectively destroy IgE-bearing lymphocytes, thus blocking IgE-mediated allergic reactions.
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