O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
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United States of America Patent
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Nov 2, 1993
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Nov 9, 1992
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Nov 9, 1992
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Abstract
O-Aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
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