Composition and treatment with biologically active peptides and antibiotic
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United States of America Patent
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Oct 19, 1993
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N/A
app pub date -
Sep 5, 1989
filing date -
Apr 17, 1989
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Expired
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Abstract
A composition comprising at least one biologically active amphiphilic peptide, said peptide being an ion channel-forming peptide, and an antibiotic selected from the class consiting of bacitracins, aminoglycosides, penicillins, monobactams, hydrophobic antibiotics, 50-S ribosome inhibitors, antibiotics having a large lipid like lactone ring, and derivatives or analogues thereof. The biologically active amphiphilic peptide and the antibiotic may be administered in amounts effective to inhibit growth of a target cell. The biologically active amphiphilic peptide and antibiotic may potentiate each other.
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