Process for preparing no-carrier-added radiohalogenated vinyl nucleosides
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United States of America Patent
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Sep 28, 1993
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Jun 26, 1991
filing date -
Jun 26, 1991
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Abstract
Reacting [.sup.* X]X- with YVaraU in the presence of a cuprous ion catalyst under anaerobic and reducing conditions produces [.sup.* X]XVaraU, where .sup.* X is a radioactive halogen, Y is a second halogen, X and Y are different halogens, and XVaraU is 1-(.beta.-D-arabinofuranosyl)-5(E)-(2-halogenovinyl) uracil, the halogen of which is X. The reaction produces an effective administrable form of [.sup.* X]XVaraU for use in diagnosis and treatment of herpes virus infections.
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